Faculty of Medicine, Dentistry and Health Sciences Department of Microbiology and Immunology

McCluskey Laboratory

Find an Expert - McCluskey

Page Contents

Include: Research Interests | Major Research Projects - Autoimmunity and Celiac Disease - The structural basis of T cell recognition - Biochemistry and cell biology of Ag presentation - Ag Presentation and disease - Immunity to Hepatitis C virus | Laboratory Staff | Recent Publications

Also see:

Professor James McCluskey's Home Page

Research Interests

Prof McCluskey's Lab is largely funded through an NHMRC Program grant held with Prof Frank Carbone, Dr Andrew Brooks, Dr Bill Heath (WEHI), Prof Ken Shortman (WEHI) and Prof Jamie Rossjohn (Monash University).  The major areas of his research program are listed below.

Major Research Projects

Autoimmunity and Celiac disease

This program of work involves using humanized mouse models of the immune response to examine pathogenesis and mechanisms in autoimmune disease. We have created transgenic mice that express the most common HLA genes associated with Type 1 diabetes, rheumatoid arthritis and celiac disease.

The current work focuses on Celiac disease, an inflammatory hypersensitivity to modified cereal proteins that is known to be strongly associated with HLA-DQ2 and HLA-DQ3(8).  The lab has created mice that independently express both these HLA-haplotypes and is developing an animal model of human Celiac disease to facilitate trials of immunotherapy that might be translated to humans.

We are also determining the the 3-dimensional X-ray crystallographic structure of HLA-DQ molecules complexed to wheat gliadin peptides as a precursor to creating multimeric agents from these structures.  This will allow diagnostic tracking of "Celiac" T cells in humans and in the mouse model.

Although celiac disease is not strictly "autoimmune" in origin it does have some autoimmune aspects such as production of antibodies to tissue transglutaminase. Therefore it is hoped that these studies will cast light on the factors that initiate and maintain other autoimmune responses such as those that occur in Type 1 diabetes mellitus.

Professor J McCluskey - Head of Department
Dr Catherine L. Keech
Dr ZhenJun Chen

top of page

 

Key collaborators

Prof Jamie Rossjohn, The Department of Biochemistry & Molecular Biology, School of Biomedical Sciences, Monash University
Dr Hugh Reid and Ms Kate Henderson, Monash University
Dr Bob Anderson, Walter and Eliza Hall Medical Research Institute and Royal Melbourne Hospital

References
  1. Chen Z, de Kauwe AL, Keech C, Wijburg O, SImpfendorfer K, Alexander WS, McCluskey J. Humanised transgenic mice expressing HLA DR4-DQ3 haplotype: reconstitution of phenotype and HLA-restricted T-cell responses. Tissue Antigens 2006; 68: 210-219.
  2. Chen Z, Dudek N, Wijburg, O, Strugnell R, Brown L, Deliyannis G, Koentgen F, Gordon TP, McCluskey J. A 320-kilobase artificial chromosome encoding the human HLA DR3-DQ2 MHC haplotype confers HLA restriction in transgenic mice. J Immunol 2002; 168(6): 3050-6.
  3. Anderson RP, Degano P, Godkin AJ, Jewell DP, Hill AVS. In vivo antigen challenge in coeliac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T cell epitope. Nature Medicine 2000; 6: 337-342.
top of page

The structural basis of T cell recognition

This program of work involves understanding the 3-dimensional X-ray crystallographic structure of HLA molecules, T cell receptors and co-complexes of these molecules.

The aim of the research is to determine the rules of T cell recognition and the basis of T cell signalling. T cell allorecognition occurs when T cells recognize foreign or allogeneic HLA molecule such as in organ transplantation.

A second major aim of this program is to determine the structural basis for T cell allorecognition of foreign HLA molecules. This understanding is crucial to transplantation rejection and graft versus host disease.

The studies involve human receptors and HLA molecules. The work is carried out in collaboration with scientists of the Victorian Transplantation and Immunogenetics Service (VTIS) an arm of the Australian Red Cross Blood Service.

Much of the work is also a collaboration with Dr Scott Burrows, Queensland Institute of Medical Research. The structural determinations are a collaborative effort with A/Professor Jamie Rossjohn and his team from Monash University.

Professor J McCluskey - Head of Department
Dr Lars Kjer-Nielsen
Ms Luda Kostenko
Dr Mandvi Bharadwaj

top of page

 

Key collaborators

Prof Jamie Rossjohn, The Department of Biochemistry & Molecular Biology
School of Biomedical Sciences, Monash University Ms Kate Henderson, Monash University
Dr Anthony Purcell, Dept. Biochemistry, Bio21 Institute
Dr Andrew Brooks, Microbiology and Immunology
Dr Brian Tait and Ms Rhonda Holdsworth,, Victorian Transplantation and Immunogenetics Service (VTIS)
Dr Scott Burrows, Queensland Institute of Medical Research

References
  1. Tynan FE, Reid HH, Kjer-Nielsen L, Miles JJ, Wilce MC, Kostenko L, Borg NA, Williamson NA, Beddoe T, Purcell AW, Burrows SR, McCluskey J, Rossjohn J. A T-cell receptor flattens a bulged antigenic peptide presented by a major histocompatiblity complex class 1 molecule. Nat Immunol 2007; 8(3): 268-276.
  2. Turner SJ, Doherty PC, McCluskey J, Rossjohn J. Structural determinants of T-cell receptor bias in immunity. Nat Rev Immunol 2006; 6(12): 883-894.
  3. Kjer-Nielsen L, Borg NA, Pellicci DG, Beddoe T, Kostenko L, Clements CS, Williamson NA, Smyth MJ, Besra GS, Reid HH, Bharadwaj M, Godfrey DI, Rossjohn J, McCluskey J. A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition. J Exp Med 2006; 203(3): 661-673.
  4. Hoare HL, Sullivan LC, Pietra G, Clements CS, Lee EJ, Ely LK, Beddoe T, Falco M, Kjer-Nielsen L, Reid HH, McCluskey J, Moretta L, Rossjohn J, Brooks AG. Structural basis for a major histocompatibility complex class Ib-restricted T cell response. Nat Immunol 2006; 7(3): 256-264.
  5. Borg NA, Ely LK, Beddoe T, Macdonald WA, Reid HH, Clements CS, Purcell AW, Kjer-Nielsen L, Miles JJ, Burrows SR, McCluskey J*, Rossjohn J*. The CDR3 regions of an immunodominant T cell receptor dictate the 'energetic landscape' of peptide-MHC recognition. Nat Immunol 2005; 6: 171-180.
  6. Kjer-Nielsen L, Dunstone MA, Kostenko L, Ely L, Beddoe T, Mifsud NA, Anthony W, Purcell AW, Brooks AG, McCluskey J*, Rossjohn J*. Crystal structure of the human T cell Receptor CD3eg heterodimer complexed to the therapeutic mAb OKT3. Proc Natl Acad Sci (USA) 2004; 101(20): 7675-80.
  7. Kjer-Nielsen L, Clements CS, Purcell AW, Brooks AG, Whisstock JC, Burrows SR, *McCluskey J, *Rossjohn J. A Structural Basis for the Selection of Dominant alpha beta T Cell Receptors in Antiviral Immunity. Immunity 2003; 18(1): 53-64.
top of page

Biochemistry and cell biology of Ag presentation

This program aims to understand the steps involved in loading peptide Ag into the cleft of HLA molecules. The project examines the nature of the HLA-peptide repertoire, the structural basis of peptide specificity and the biochemical processes involved in creating, transporting and loading peptide into MHC molecules.

We are particularly interested in the role of the ER chaperone tapasin, that appears to edit bound peptides and enhance peptide repertoire of class I molecules. Another aspect of the research is to understand the strategies used by viruses to evade Ag presentation and hence to avoid recognition by CTL.

This work is also carried out in collaboration with scientists of the Victorian Transplantation and Immunogenetics Service (VTIS) an arm of the Australian Red Cross Blood Service.

Much of the work is also a collaboration with Dr Scott Burrows, Queensland Institute of Medical Research. The structural determinations are a collaborative effort with A/Professor Jamie Rossjohn and his team from Monash University.

Professor J McCluskey - Head of Department
Dr Lars Kjer-Nielsen
Ms Luda Kostenko
Dr Mandvi Bharadwaj
Philippa Saunders

top of page

 

Key collaborators

Prof Jamie Rossjohn, The Department of Biochemistry & Molecular Biology
School of Biomedical Sciences, Monash University Ms Kate Henderson, Monash University
Dr Anthony Purcell, Dept. Biochemistry, Bio21 Institute
Dr Andrew Brooks, Microbiology and Immunology
Dr Brian Tait and Ms Rhonda Holdsworth,, Victorian Transplantation and Immunogenetics Service (VTIS)
Dr Scott Burrows, Queensland Institute of Medical Research

References
  1. Turner SJ, Kedzierska K, Komodromou H, La Gruta NL, Dunstone, MA, Webb AI, Webby R, Walden H, Xie W, McCluskey J, Purcell AW, Rossjohn J, Doherty PC. Lack of prominent peptide/MHC features limits T cell receptor repertoire diversity in virus-specific CD8+ T populations. Nat Immunol 2005; 6(4): 382-389.

    2. *Joint Senior authors

  2. Clements CS, Kjer-Nielsen L, Kostenko L, Hoare HL, Dunstone MA, Moses E, Freed K, Brooks AG, Rossjohn J, * & McCluskey J.* The crystal structure of HLA-G: a non-classical MHC class I molecule expressed at the fetal-maternal interface. (*Joint senior & corresponding author) Proc Natl Acad Sci (USA) 2005; 102(9): 3360-3365.
  3. Webb AI, Borg NA, Dunstone MA, Kjer-Nielsen L, Beddoe T, McCluskey J, Carbone FR, Bottomley SP, Aguilar MI, Purcell, AW, Rossjohn J. The Structure of H-2K(b) and K(bm8) Complexed to a Herpes Simplex Virus Determinant: Evidence for a Conformational Switch That Governs T Cell Repertoire Selection and Viral Resistance. J Immunol 2004; 173(1): 402-9.
  4. McCluskey J, Rossjohn J, Purcell AW. TAP Genes and Immunity. Current Opinions in Immunology 2004; 16: 651-659.
  5. Purcell AW, Gorman J, Garcia-Peydró M, Paradela A, Burrows S R, Talbo GH, Laham N, Peh CA, Reynolds EC, Lopez de Castro JA, McCluskey J. Quantitative and qualitative influence of tapasin on the class I peptide repertoire. J Immunol 2001; 166: 1016-1027.
  6. Zernich D, Purcell AW, Macdonald WA, Kjer-Nielsen L, Ely LK, Laham N, Crockford T, Mifsud NA, Tait BD, Holdsworth R, Brooks AG, Bottomley SP, Beddoe T, Peh CA, Rossjohn J, McCluskey J. Natural HLA Class I polymorphism controls the pathway of antigen presentation and susceptibility to viral evasion. J Exp Med 2004; 200: 13-24.
  7. Webb AI, Dunstone MA, Chen W, Aguilar M-I, Chen Q, Chang, L, Kjer-Nielsen L, Beddoe T, McCluskey J, Rossjohn J, Purcell AW. Functional and structural characteristics of NY-ESO-1 related HLA-A2 restricted epitopes and the design of a novel immunogenic analogue. J Biol Chem 2004; 279(22): 23438-46.
  8. Margulies DH, McCluskey J. The Major Histocompatibility Complex and its Encoded Proteins. In: Paul WE, editor. Fundamental Immunology. New York: Lippincott-Raven: 2003.
  9. Macdonald WA, Purcell AW, Mifsud N, Ely LK, Williams DS, Gorman JJ, Clements CS, Kjer-Nielsen L, Koelle DM, Burrows SR, Tait BD, Holdsworth R, Brooks AG, Lovrecz GO, Lu GO, Rossjohn J, McCluskey J. A Naturally Selected Dimorphism within the HLA-B44 Supertype Alters Class I Structure, Peptide Repertoire and T Cell Recognition. J Exp Med 2003; 198(5): 679-91.
    Cited as a "Must Read" Faculty of 1000
top of page

Ag Presentation and disease

This program examines the mechanisms and outcomes of aberrant Ag presentation, usually as a consequence of post-translational modification of self-peptides.

Several systems fall into this category. Firstly, the deamidation of selected glutamine residues in cereal proteins such as gliadins in celiac disease. Here we are mainly interested in which residues are deamidated to create bona fide DQ-binding ligands and to understand the structural basis of this improved class II-binding.

Secondly, we are studying hypersensitivity to the HIV reverse transcriptase inhibitor, abacavir that is strongly associated with HLA-B57. We believe this is a CD8 T cell response to abacavir-altered HLA-B57/peptide complex. Efforts are underway to unravel the biochemistry and structural basis of this reaction.

Thirdly, we are studying the effects of Salmonella infection on the structure, peptide repertoire and recognition of HLA-B27. HLA-B27 is strongly associated with the rheumatic disorder Ankylosing Spondylitis that is sometimes triggered by mucosal infection with organisms such as Salmonella. We hypothesis that mucosal infection induces a conformational or structural change in B27 that allows an enhanced immune response leading to autoimmunity.

Professor J McCluskey - Head of Department
Dr Catherine L. Keech
Dr Lars Kjer-Nielsen
Ms Luda Kostenko
Dr Mandvi Bharadwaj
Dr Roya Arabi
Philippa Saunders

top of page

 

Key collaborators

Prof Jamie Rossjohn, Dr Hugh Reid and Ms Kate Henderson, The Department of Biochemistry & Molecular Biology, School of Biomedical Sciences, Monash University Ms Kate Henderson, Monash University
Dr Anthony Purcell, Dept. Biochemistry, Bio21 Institute
Professor Dick Strugnell and Dr Odlilia Wijburg, Microbiology and Immunology
Dr Brian Tait and Ms Rhonda Holdsworth,, Victorian Transplantation and Immunogenetics Service (VTIS)
Dr Simon Mallal and Dr Annalise Martin, Royal Perth Hospital, W.A.
Dr Lionel Schachna, Austin Repatriation Hospital, Melbourne
Dr Bob Anderson, Walter and Eliza Hall Medical Research Institute and Royal Melbourne Hospital

References
  1. Martin AM, Nolan D, Gaudieri S, Almeida CA, Nolan R, James, I, Carvalho F, Phillips E, Christiansen FT, Purcell AW, McCluskey J, Mallal S. Predisposition to Abacavir Hypersensitivity Conferred by HLA-B*5701 and a Haplotypic Hsp70-Hom variant. Proc Natl Acad Sci (USA) 2004; 101(12): 4180-5.
  2. Anderson RP, Degano P, Godkin AJ, Jewell DP, Hill AVS. In vivo antigen challenge in coeliac disease identifies a single transglutaminase-modified peptide as the dominant A-gliadin T cell epitope. Nature Medicine 2000; 6: 337-342.
  3. Purcell AW, Kelly A, Peh CA, Dudek N, McCluskey J. Endogenous and exogenous factors contributing to the surface expression of HLA B27 on mutant APC. Human Immunol 2000; 61(2): 140-147
  4. Peh CA, Burrows SR, Barnden M, Khanna R, Cresswell P, Moss DJ, McCluskey J. HLA B27-restricted antigen presentation in the absence of tapasin reveals polymorphism in generic mechanisms of HLA class I-peptide loading. Immunity 1998; 8: 531-542.
top of page

Immunity to Hepatitis C Virus

Hepatitis C virus (HCV) is a major public health problem, affecting an estimated 170 million people worldwide. While a small proportion of HCV infected individuals clear the virus spontaneously, the majority progress to chronic infection and are at serious risk of developing liver cirrhosis and hepatocellular carcinoma.

In order to understand the correlates of protective immunity in HCV infection this program is aimed at the investigation of the immune response in different cohorts of HCV infected donors (persistent infection versus spontaneous clearance of virus). A major emphasis is on intravenous drug users (IDUs) who remain HCV negative in spite of recurrent exposure to HCV due to their high-risk behaviour. Other interesting cohorts include IDUs with multiple strains of HCV and donors who have cleared HCV and remain HCV free in spite of continuing injecting drug use.
Some of the aspects under investigation include- identification of  immunogenic T cell determinants from the different HCV genotypes, functional characterisation of HCV specific T cells in different disease outcomes, cellular immune response in IDU donors who carry more than one HCV genotype, T cell repertoire during acute infection leading to resolution or chronic infection and analysis of T cell receptors. Collaborative work is also underway on vaccine delivery modalities.

Much of this work is being carried out in collaboration with scientists at the Burnet Institute, Royal Melbourne hospital and the VIDRL. Some other key collaborators include scientists of the Victorian Transplantation and Immunogenetics Service (VTIS) and the Queensland Institute of Medical Research.

Professor J McCluskey - Head of Department
Dr Mandvi Bharadwaj
Dr DuangTawan Thammanichanond
Sarah Moneer
James Tan
Usha Kiranmayee Nivarthi

top of page

 

Key Collaborators
A/Professor Margaret Hellard-Macfarlane Burnet Centre for Medical Research
Dr Cambell Aitken-Macfarlane Burnet Centre for Medical Research
A/Prof David Jackson-University of Melbourne
Dr Joe Torresi- Royal Melbourne Hospital
Dr Scott Bowden- VIDRL
Dr Heidi Drummer- Macfarlane Burnet Centre for Medical Research
Dr Patricia Yotnda- Baylor College of Medicine, USA

Relevant References

  1. Torresi J, Bharadwaj M, Jackson DC, Gowans EJ. Neutralising antibody, CTL and dendritic cell responses to hepatitis C virus: a preventative vaccine strategy. Current Drug Targets 2004; 5(1): 41-56
  2. Belz GT, Smith CM, Bharadwaj M, Rice AM and Jackson DC. Dendritic cells as targets for vaccine design. Cytotherapy 2004; 6: 1-11.
  3. Gowans EJ, Jones KL, Bharadwaj M, Jackson DC. Prospects for dendritic cell vaccination in persistent infection with hepatitis C virus. J Clin Virol 2004; 30(4): 283-290
  4. Aitken C, Bharadwaj M, Bowden S, Hellard M. Molecular epidemiology of the hepatitis C virus in a social network of injecting drug users: an update. Sociedad Iberoamericana de Información Científica (Salud): Expertos Invitados.
top of page

Laboratory Staff

Dr Roya Arabi, PhD Student
Dr Hope Vu Dinh, PhD Student
Ms Philippa Saunders, PhD Student
Ms Usha Kiranmayee Nivarthi, PhD Student
Ms Luda Kostenko, Research Assistant
Ms Sarah Moneer, PhD Student
Ms Michele Milne, Hons Student
Ms Patricial Illing, Hons Student
Ms Bronwun Meehan, Research Assistant

Visitors
Dr Christina Bade-Doeding
Ms Sidonia Eckle

Postdoctoral Research Fellows
Dr Catherine L. Keech
Dr ZhenJun Chen
Dr Lars Kjer-Nielsen
Dr Mandvi Bharadwaj

top of page

Recent Publications: 2007-Present

List of Publications prior to 2007

  1. Beddoe T, Chen Z, Clements C, Ely L, Bushell SR, Vivian JP, Kjer-Nielsen L, Pang SS, Dunstone MA, Liu VC, MacDonald WA, Perugini M, Wilce MCJ, Burrows SR, Purcell A, Tiganis T, Bottomley SP, McCluskey J, Rossjohn J. Antigen Ligation Triggers a Conformational Change within the Constant Domain of the αβ T Cell Receptor. Immunity 2009; 30: 777-88.
  2. De Kauwe AL, Chen Z, Anderson P, Keech C, Price JD, Wijburg O, Jackson D, Ladhams J, Allison J, McCluskey J. Resistance to Celiac Disease in Humanized HLA-DR3-DQ2-Transgenic Mice Expressing Specific Anti-Gliadin CD4+ T cells. Journal of Immunology 2009; 182: 7440-7450.
  3. Gras S, Burrows SR, Kjer-Nielsen L, Clements CS, Liu YC, Bell MJ, Brooks A, Purcell A, McCluskey J, Sullivan L, Rossjohn J. The shaping of T cell receptor recognition by self-tolerance. Immunity 2009; 30: 193-203.
  4. Archbold JK, Macdonald WA, Burrows SR, Rossjohn J, McCluskey J. T-cell allorecognition: a case of mistaken identity or déjà vu? Trends Immunol 2008 May; 29(5):220-6.
  5. Wynn KK, Fulton Z, Cooper L, Silins SL, Gras S, Archbold JK, Tynan FE, Miles JJ, McCluskey J, Burrows SR, Rossjohn J, Khanna R. Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection. Blood 2008 Apr 15;111(8): 4283-92.
  6. Wun KS, Borg NA, Kjer-Nielsen L, Beddoe T, Koh R, Richardson SK, Thakur M, Howell AR, Scott-Browne JP, Gapin L, Godfrey DI, McCluskey J, Rossjohn J. A minimal binding footprint on CD1d-glycolipid is a basis for selection of the unique human NKT TCR. J Exp Med 2008 Apr 14;205(4): 939-49.
  7. Godfrey DI, Rossjohn J, McCluskey J. The fidelity, occasional promiscuity, and versatility of T cell receptor recognition. Immunity 2008 Mar;28(3): 304-14.
  8. Unanue ER, McCluskey J. Dressing for the occasion: APCs make antigens presentable. Curr Opin Immunol 2008 Feb;20(1): 49-51.
  9. Gras S, Kjer-Nielsen L, Burrows SR, McCluskey J, Rossjohn J. T-cell receptor bias and immunity. Curr Opin Immunol 2008 Feb;20(1): 119-25.
  10. Archbold JK, Ely LK, Kjer-Nielsen L, Burrows SR, Rossjohn J, McCluskey J, Macdonald WA. T cell allorecognition and MHC restriction--A case of Jekyll and Hyde? Mol Immunol 2008 Feb;45(3): 583-98.
  11. Mifsud NA, Purcell AW, Chen W, Holdsworth R, Tait BD, McCluskey J. Immunodominance hierarchies and gender bias in direct T(CD8)-cell alloreactivity. Am J Transplant 2008 Jan;8(1): 121-32.
  12. Henderson KN, Reid HH, Borg NA, Broughton SE, Huyton T, Anderson RP, McCluskey J, Rossjohn J. The production and crystallization of the human leukocyte antigen class II molecules HLA-DQ2 and HLA-DQ8 complexed with deamidated gliadin peptides implicated in coeliac disease. Acta Crystallogr Sect F Struct Biol Cryst Commun 2007 Dec 1;63(Pt 12): 1021-5.
  13. Dudek NL, Maier S, Chen ZJ, Mudd PA, Mannering SI, Jackson DC, Zeng W, Keech CL, Hamlin K, Pan ZJ, Davis-Schwarz K, Workman-Azbill J, Bachmann M, McCluskey J, Farris AD. T cell epitopes of the La/SSB autoantigen in humanized transgenic mice expressing the HLA class II haplotype DRB1*0301/DQB1*0201. Arthritis Rheum 2007 Oct;56(10): 3387-98.
  14. Scott-Browne JP, Matsuda JL, Mallevaey T, White J, Borg NA, McCluskey J, Rossjohn J, Kappler J, Marrack P, Gapin L. Germline-encoded recognition of diverse glycolipids by natural killer T cells. Nat Immunol 2007 Oct;8(10): 1105-13.
  15. Borg NA, Wun KS, Kjer-Nielsen L, Wilce MC, Pellicci DG, Koh R, Besra GS, Bharadwaj M, Godfrey DI, McCluskey J, Rossjohn J. CD1d-lipid-antigen recognition by the semi-invariant NKT T-cell receptor. Nature 2007 Jul 5;448(7149): 44-9.
  16. Purcell AW, McCluskey J, Rossjohn J. More than one reason to rethink the use of peptides in vaccine design. Nat Rev Drug Discov 2007 May;6(5): 404-14.
  17. Rossjohn J, McCluskey J. How a home-grown T cell receptor interacts with a foreign landscape. Cell 2007 Apr 6;129(1): 19-20.
  18. Burrows JM, Wynn KK, Tynan FE, Archbold J, Miles JJ, Bell MJ, Brennan RM, Walker S, McCluskey J, Rossjohn J, Khanna R, Burrows SR. The impact of HLA-B micropolymorphism outside primary peptide anchor pockets on the CTL response to CMV. Eur J Immunol 2007 Apr;37(4): 946-53.
  19. Clements CS, Kjer-Nielsen L, McCluskey J, Rossjohn J. Structural studies on HLA-G: implications for ligand and receptor binding. Hum Immunol 2007 Apr;68(4): 220-6.
  20. Tynan FE, Reid HH, Kjer-Nielsen L, Miles JJ, Wilce MC, Kostenko L, Borg NA, Williamson NA, Beddoe T, Purcell AW, Burrows SR, McCluskey J, Rossjohn J. A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule. Nat Immunol 2007 Mar;8(3): 268-76.
  21. Borg NA, Kjer-Nielsen L, McCluskey J, Rossjohn J. Structural insight into natural killer T cell receptor recognition of CD1d. Adv Exp Med Biol 2007;598: 20-34.

 

top of page