Brown Laboratory
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Include: Research interests | Laboratory Staff | Recent publications | Links
Research Interests
All research currently performed by the team involves investigation and control of influenza.
Immunology
- Interaction of influenza virus and dendritic cells
- Manipulation of immunogen composition to perturb activation pathways in dendritic cells
- Passive antibody transfer for prevention and control of influenza (with Immuron Ltd)
- The role of costimulation in the priming of effector and memory CD8+ T cells against influenza (with Andrew Lew, Yifan Zhan and Shirley Seah, WEHI)
Virology
- The role of the influenza protein PB1-F2 in the pathogenesis of influenza
- Location of the site of binding of an innate inhibitor of influenza to the virus particle
- The role of amino acids within the cytoplasmic tail of the viral hemagglutinin in budding and particle formation
- Progression of H5N1 and seasonal influenza within and external to the respiratory tract in ferrets (with Deborah Middleton, AAHL)
- Factors governing animal-to-animal transmission of different influenza virus strains
- Electron microscopic evaluation of the mechanism of action of anti-influenza drugs (with Biota)
- Factors responsible for the acquisition of high pathogenicity phenotype of H5N1 in mammals (with Deborah Middleton and Sandra Sapats, AAHL, and Steve Rockman, CSL Ltd)
Vaccinology
- Effect of combining a CTL-inducing component with the seasonal split virus vaccine on vaccine outcome (with David Jackson)
- Identifying the effect of gene constellation of vaccine seed viruses of vaccine yield (with Steve Rockman, CSL Ltd)
- Evaluation of immunogenicity and protective efficacy of H5N1 and swine-origin H1N1 vaccines in ferrets (with AAHL, CSL Ltd and WHO Centre for Influenza Reference and Research)
- Evaluation of nanopatch technology for the delivery of influenza vaccines (with Mark Kendall and colleagues, UQ)
- Evaluation of plant-derived influenza hemagglutinin as a vaccine candidate (with Diane Webster and colleagues, Monash University)
Laboratory Staff
Brad Gilbertson, Senior Research Officer
Julie McAuley, Senior Research Officer
Lisa Ioannidis, PhD student
Joanna Cobbin, PhD student
Kathryn Edenborough, PhD student
Alex Courtney, PhD student
Jeff Butler, PhD student (based at AAHL)
Wy Ching Ng, Research Assistant
Emily Fairmaid, Research Assistant
Recent publications
List of Publications prior to 2007
- Middleton D, Rockman S, Pearse M, Barr I, Lowther S, Klippel J, Ryan D, Brown L. Evaluation of vaccines for H5N1 influenza virus in ferrets reveals the potential for protective single-shot immunization. J Virol 2009 Aug; 83(15): 7770-78. Epub 2009 May 20.
- Ng WC, Gilbertson B, Lim B, Zeng W, Jackson DC, Brown LE. Lipopeptide vaccines illustrate the potential role of subtype-crossreactive T cells in the control of highly virulent influenza. Influenza Other Respi Viruses 2009 Jul; 3(4): 177-82.
- Doherty P, Brown L, Kelso A, Thomas PG. Immunity to avian influenza A viruses. OIE Revue Scientifique et Technique 2009; 28: 175-185.
- Brown L, Kelso A. Prospects for an influenza vaccine that induces cross-protective cytotoxic T lymphocytes. Immunology and Cell Biology 2009; 87: 300-308.
- Turner S, Brown L, Doherty P, Kelso A. Q&A: What have we found out about the influenza A (H1N1) 2009 pandemic virus? Journal of Biology 2009; 8: 69.
- Johnson S, Zhan Y, Sutherland RM, Mount A, Bedoui S, Brady JL, Carrington EM, Brown L, Belz GT, Heath W, Lew AM. Selected toll-like receptor ligands and viruses promote helper-independent cytotoxic T cell priming by upregulating CD40L on dendritic cells. Immunity 2009; 30: 218-227.
- Sanders M, Deliyannis G, Pearse M, McNamara M, Brown L. Single dose intranasal immunization with ISCOMATRIX vaccines to elicit antibody-mediated clearance of influenza virus requires delivery to the lower respiratory tract. Vaccine 2009; 27: 2475-2482.
- Chua B, Eriksson EMY, Brown L, Zeng W, Gowans E, Torresi J, Jackson D. A self-adjuvanting lipopeptide-based vaccine candidate for the treatment of hepatitis C virus infection. Vaccine 2008; 26: 4866-4875.
- Reading P, Bozza S, Gilbertson B, Tate M, Moretti S, Job E, Crouch E, Brooks A, Brown L, Romani L, Bottazzi B, Mantovani A. Antiviral activity of the long chain pentraxin PTX3 against influenza viruses. Journal of Immunology 2008; 180: 3391-3398.
- Jones KL, Brown L, Eriksson EMY, Ffrench RA, Latour PA, Loveland BE, Wall DM, Roberts SK, Jackson D, Gowans EJ. Human dendritic cells pulsed with specific lipopeptides stimulate autologous antigen-specific T cells without the addition of exogenous maturation factors. Journal of Viral Hepatitis 2008; 15: 761-772.
- Clements A, Jenney A, Gabbe J, Brown L, Deliyannis G, Hartland E, Pearse M, Maloney M, Wesselingh S, Wijburg O, Strugnell R. Targeting subcapsular antigens for prevention of Klebsiella pneumoniae infections. Vaccine 2008; 26: 5649-53.
- Brown L, Deliyannis G, Kedzierska K, Lau YF, Ng WC, Zeng W, Gilbertson B, Lim B, Cobbin JCA, Jackson D, Turner S, Kelso A. Lipopeptide vaccines illustrate the potential role of subtype-crossreactive T cell responses in the control of seasonal and pandemic influenza. In: Options for the Control of Influenza VI. International Medical Press(London). 2008; 199-201.
- Murphy AM, Westwood JAW, Brown L, Teng MWLT, Moeller MM, Smyth M, Hwu PH, Kershaw MHK. Antitumor activity of dual-specific T cells and influenza virus. Cancer Gene Therapy 2007; 14: 499-508.
- Hurt ACH, Selleck PS, Komadina NK, Shaw RS, Brown L, Barr IGB. Susceptibility of highly pathogenic A (H5N1) avian influenza viruses to the neuraminidase inhibitors and adamantanes. Antiviral Research 2007; 73: 228-231
Links
Immunology Group of Victoria (IgV)