Peter Doherty PhD AC FAA FAS

Nobel Laureate 1996

 

Laureate Professor

Room 2.06A
Department of Microbiology and Immunology
The University of Melbourne
Victoria 3010
Australia

Tel:   +61 3 8344 7968
Fax:   +61 3 8344 7990
Email:   pcd@unimelb.edu.au

 
 

Page Contents

Include: Bio | Academic degrees | Honorary degrees | Professional appointments | Research Interests | Recent Publications (2007 — present)

Also see:

Full CV

Bio

Professor Peter Doherty shared the Nobel Prize in Physiology or Medicine in 1996 with Swiss colleague Rolf Zinkernagel, for their discovery of how the immune system recognises virus-infected cells. He was Australian of the Year in 1997, and has since been commuting between St Jude Children’s Research Hospital in Memphis and the Department of Microbiology and Immunology at the University of Melbourne. His research is mainly in the area of defence against viruses. He regularly devotes time to delivering public lectures, writing articles for newspapers and magazines and participating in radio discussions.

Peter Doherty graduated from the University of Queensland in Veterinary Science and became a veterinary officer. Moving to Scotland, he received his PhD from the University of Edinburgh Medical School. He is the first person with a veterinary qualification to win a Nobel Prize.

Peter is also the author of several books, including “A Light History of Hot Air” and “The Beginners Guide to Winning the Nobel Prize”.

Academic Degrees:

1962: BVSc, University of Queensland, Australia (Veterinary Science)
1966: MVSc, University of Queensland, Australia (Veterinary Science)
1970: PhD, University of Edinburgh, Scotland (Pathology)

Honorary Degrees:

1995: DVSc, University of Queensland, Australia
1996: DSc, Australian National University
1997: DSc, University of Edinburgh, Scotland
1997: DSc, Tufts University, Medford, Massachusetts
1998: DMedSc, Rhodes College, Memphis, Tennessee
1998: DPh, Kyorin University, Japan
1998: DSc, Warsaw Agricultural University, Warsaw, Poland
1999: DSc, Latrobe University, Melbourne, Australia
2000: DSc, Imperial College, University of London, United Kingdom
2000: DSc, Autonomous University of Barcelona, Spain
2000: DSc, North Carolina State University, Raleigh-Durham, North Carolina
2001: DSc, University of Guelph, Ontario, Canada
2001: DSc, University of Pennsylvania, Philadelphia, Pennsylvania
2002: DSc, Michigan State University, Lansing, Michigan
2002: DSc, University of Illinois at Urbana-Champaign, Urbana, Illinois
2003: DSc, University of Technology, Sydney, Australia

Professional Appointments:

1988 — present: Member Department of Immunology (Michael F. Tamer Chair of Biomedical Research), St Jude Children’s Research Hospital, Memphis, Tennessee (currently 3 months per year)

2002 — present: Laureate Professor, Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria (currently 9 months per year)

Research Interests

(This will be a few paragraphs)

Recent Publications (2007 — present)

Original Articles

  1. Jenkins MR, La Gruta NL, Doherty PC, Trapani JA, Turner SJ, Waterhouse NJ. Visualizing CTL activity for different CD8(+) effector T cells supports the idea that lower TCR/epitope avidity may be advantageous for target cell killing. Cell Death Differ 2009; Jan 9. [Epub ahead of print]
  2. Schlub TE, Venturi V, Kedzierska K, Wellard C, Doherty PC, Turner SJ, Ribeiro RM, Hodgkin PD, Davenport MP. Division-linked differentiation can account for CD8(+) T-cell phenotype in vivo. Eur J Immunol 2009; 39(1): 67-77.
  3. Kedzierska K, Guillonneau C, Gras S, Hatton LA, Webby R, Purcell AW, Rossjohn J, Doherty PC, Turner SJ. Complete modification of TCR specificity and repertoire selection does not perturb a CD8+ T cell immunodominance hierarchy. Proc Natl Acad Sci U S A 2008; 105(49): 19408-13.
  4. Kedzierski L, Curtis JM, Doherty PC, Handman E, Kedzierska K. Decreased IL-10 and IL-13 production and increased CD44(hi) T cell recruitment contribute to Leishmania major immunity induced by non-persistent parasites. Eur J Immunol 2008; 38(11): 3090-100.
  5. Jenkins MR, Trapani JA, Doherty PC, Turner SJ. Granzyme K expressing cytotoxic T lymphocytes protects against influenza virus in granzyme AB-/- mice. Viral Immunol 2008; 21(3): 341-6.
  6. Jenkins MR, Mintern J, La Gruta NL, Kedzierska K, Doherty PC, Turner SJ. Cell cycle-related acquisition of cytotoxic mediators defines the progressive differentiation to effector status for virus-specific CD8+ T cells. J Immunol 2008; 181(6): 3818-22.
  7. Miller A, Center RJ, Stambas J, Deliyannis G, Doherty PC, Howard JL, Turner SJ, Purcell DF. Sindbis virus vectors elicit hemagglutinin-specific humoral and cellular immune responses and offer a dose-sparing strategy for vaccination. Vaccine 2008; 26(44): 5641-8.
  8. Kedzierska K, Thomas PG, Venturi V, Davenport MP, Doherty PC, Turner SJ, La Gruta NL. Terminal deoxynucleotidyltransferase is required for the establishment of private virus-specific CD8+ TCR repertoires and facilitates optimal CTL responses. J Immunol 2008; 181(4): 2556-62.
  9. Kedzierska K, Venturi V, Valkenburg SA, Davenport MP, Turner SJ, Doherty PC. Homogenization of TCR repertoires within secondary CD62L(high) and CD62L(low) virus-specific CD8(+) T cell populations. J Immunol 2008; 180(12): 7938-47.
  10. Rutigliano JA, Doherty PC, Franks J, Morris MY, Reynolds C, Thomas PG. Screening monoclonal antibodies for cross-reactivity in the ferret model of influenza infection. J Immunol Methods 2008; 336(1): 71-7.
  11. LaGruta NL, Thomas PG, Webb AI, Dunstone MA, Cukalac T, Doherty PC, Purcell AW, Rossjohn J, Turner SJ. Epitope-specific TCRbeta repertoire diversity imparts no functional advantage on the CD8+ T cell response to cognate viral peptides. Proc Natl Acad Sci U S A 2008; 105(6): 2034-9.
  12. Mintern JD, Guillonneau C, Carbone FR, Doherty PC, Turner SJ. Cutting edge: Tissue-resident memory CTL down-regulate cytolytic molecule expression following virus clearance. J Immunol 2007; 179(11): 7220-4.
  13. Venturi V, Kedzierska K, Tanaka MM, Turner SJ, Doherty PC, Davenport MP. Method for assessing the similarity between subsets of the T cell receptor repertoire. J Immunol Methods 2008; 329(1-2): 67-80.
  14. Day EB, Zeng W, Doherty PC, Jackson DC, Kedzierska K, Turner SJ. The Context of Epitope Presentation Can Influence Functional Quality of Recalled Influenza A Virus-Specific Memory CD8+ T Cells. J Immunol 2007; 179(4): 2187-94.
  15. Brown SA, Hurwitz JL, Zirkel A, Surman S, Takimoto T, Alymova I, Coleclough C, Portner A, Doherty PC, Slobod KS. A recombinant Sendai virus is controlled by CD4+ effector T cells responding to a secreted HIV-1 envelope glycoprotein. J Virol 2007; 81(22): 12535-42.
  16. Jenkins MR, Kedzierska K, Doherty PC, Turner SJ. Heterogeneity of effector phenotype for acute phase and memory influenza A virus-specific CTL. J Immunol 2007; 179(1): 64-70.
  17. Turner SJ, Olivas E, Gutierrez A, Diaz G, Doherty PC. Disregulated influenza A virus-specific CD8+ T cell homeostasis in the absence of IFN-gamma signaling. J Immunol 2007; 178(12): 7616-22.
  18. Kedzierska K, Stambas J, Jenkins MR, Keating R, Turner SJ, Doherty PC. Location rather than CD62L phenotype is critical in the early establishment of influenza-specific CD8+ T cell memory. Proc Natl Acad Sci U S A 2007; 104(23): 9782-7.
  19. Venturi V, Kedzierska K, Turner SJ, Doherty PC, Davenport MP. Methods for comparing the diversity of samples of the T cell receptor repertoire. J Immunol Methods 2007; 321(1-2): 182-95.
  20. Thomas PG, Brown SA, Keating R, Yue W, Morris MY, So J, Webby RJ, Doherty PC. Hidden epitopes emerge in secondary influenza virus-specific CD8+ T cell responses. J Immunol 2007; 178(5): 3091-8.
  21. Keating R, Yue W, Rutigliano JA, So J, Olivas E, Thomas PG, Doherty PC. Virus-specific CD8+ T cells in the liver: armed and ready to kill. J Immunol 2007; 178(5): 2737-45.
  22. Ranasinghe C, Turner SJ, McArthur C, Sutherland DB, Kim JH, Doherty PC, Ramshaw IA. Mucosal HIV-1 pox virus prime-boost immunization induces high-avidity CD8+ T cells with regime-dependent cytokine/granzyme B profiles. J Immunol 2007; 178(4): 2370-9.
  23. Stambas J, Doherty PC, Turner SJ. An in vivo cytotoxicity threshold for influenza A virus-specific effector and memory CD8(+) T cells. J Immunol 2007; 178(3): 1285-92.
  24. Denton AE, Doherty PC, Turner SJ, La Gruta NL. IL-18, but not IL-12, is required for optimal cytokine production by influenza virus-specific CD8(+) T cells. Eur J Immunol 2007; 37(2): 368-75.
Solicited reviews, book chapters and commentary
  1. Thomas PG, Doherty PC. Rules to 'prime' by. Nat Immunol 2009; 10(1): 14-6.
  2. Doherty PC, Kelso A. Toward a broadly protective influenza vaccine. J Clin Invest 2008; 118(10): 3273-3275.
  3. Stambas J, Guillonneau C, Kedzierska K, Mintern JD, Doherty PC, La Gruta NL. Killer T cells in influenza. Pharmacol Ther 2008; 120(2): 186-96.
  4. Doherty PC. Burnet, chick embryos, viruses, clones and quantitative biology. Immunol Cell Biol 2008; 86(2): 119-123.
  5. Kedzierska K, LaGruta NL, Stambas J, Turner SJ, Doherty PC. Tracking phenotypically and functionally distinct T cell subsets via T cell repertoire diversity. Mol Immunol 2008; 45(3): 607-18.
  6. Mintern JD, Guillonneau C, Turner SJ, Doherty PC. Influenza Vaccines for the Future. Immunity to Influenza. Birkhauser Publishers Ltd. Editors: Rino Rappuoli & Giuseppe Del Giudice (2007).
  7. Doherty PC. Endings and beginnings. Cell Mol Life Sci 64(1):1-2, 2007.
  8. Brent L, Cohen IR, Doherty PC, Feldmann M, Matzinger P, Ghost Lab, Holgate ST, Lachmann P, Mitchison NA, Nossal G, Rose NR, Zinkernagel R. Crystal-ball gazing--the future of immunological research viewed from the cutting edge. Clin Exp Immunol 2007; 147(1): 1-10.
  9. Doherty PC. Challenged by complexity: my twentieth century in immunology. Annu Rev Imm 2007; 25:1-19, 2007.
  10. Doherty PC, Turner SJ. The Challenge of viral immunity. Immunity 2007; 27(3): 363-5.
  11. La Gruta NL, Kedzierska K, Stambas J, Doherty PC. A question of self-preservation: immunopathology in influenza virus infection. Immunol Cell Biol 2007; 85<=/(2): 85-92.
Books:
  1. A Light History of Hot Air, Miegunyah Press, Melbourne University Publishing, September, 2007.
  2. The Beginner’s Guide to Winning the Nobel Prize”, Miegunyah Press, Melbourne University Publishing, September, 2005; Columbia University Press, NY, May 2006.

 

 


 

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