Projects

Sequence Based Typing: 14th International Workshop Project Proposal

The goals of the SBT component are as follows;
1. To collate and assess current SBT protocols for HLA typing with particular reference to the resolution of typing ambiguities.
2. To identify reference SBT labs that are able to provide limited sequencing of potential new alleles and reference sequences.
3. To complete exon 2 sequencing for incomplete HLA class II alleles and exon 2 and 3 sequencing for incomplete HLA class I alleles.
4. To collate additional HLA allele sequence information.

Sub-committees will be set up to oversee
1) Quality – review of local QA data e.g. UCLA , provision of QA panel in absence of local QA data.
2) Bioinformatics – collation and provision of available analysis and data submission tools. Liase with IMGT to incorporate all sequence data into IMGT.
3) Sub-committees will be set up for each HLA locus that will have a similar focus to the allele/haplotype groups used in previous workshops. The chairpersons would collate protocols, have input to the QA group, request cells/DNA for missing alleles, liase with bioinformatics & SIGs and steer data analysis. A communication forum will be set up using the website (http://www.microbiol.unimelb.edu.au/micro/14ihiws/).
4) Special Interest groups e.g. mutation analysis in blasts, correlation exon and promoter sequences,
RNA-SBT will be listed on the website.

Please contact the chairpersons directly to register your interest .

Chairpersons:

Dr. Marcel G.J. Tilanus,
UMC-Utrecht, Heidelberglaan 100,
Postbus P.O. Box 85500, HP H04.312,.
GA UTRECHT, the Netherlands, phone ++31 30 2506487/7665, fax ++ 31 30 2544990,
email M.Tilanus@lab.azu.nl

Dr. David Sayer,
Royal Perth Hospital, Dept of Clinical Immunology,
Wellington Street, Perth 6000, Australia,
phone ++61 8 92242899, fax ++618 92242920
email david.sayer@health.wa.gov.au

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